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Resistance Exercise Reverses Aging in Human Skeletal Muscle

The following study is one of my favorites to discuss. The name says it all and is extremely powerful. Usually, scientists are very measured in their wording. You may see a study with a name such as this:

Eur J Sport Sci. 2016 Nov;16(8):1055-63. doi: 10.1080/17461391.2016.1185164. Epub 2016 May 27.
Effects of resistance training on expression of IGF-I splice variants in younger and older men.
Ahtiainen JP, Hulmi JJ, Lehti M, Kraemer WJ, Nyman K, Selänne H, Alen M, Komulainen J, Kovanen V, Mero AA, Philippou A, Laakkonen EK, Häkkinen K.

https://www.ncbi.nlm.nih.gov/pubmed/27231807

The following study is one of my favorites to discuss. The name says it all and is extremely powerful. Usually, scientists are very measured in their wording. You may see a study with a name such as this:

Eur J Sport Sci. 2016 Nov;16(8):1055-63. doi: 10.1080/17461391.2016.1185164. Epub 2016 May 27.
Effects of resistance training on expression of IGF-I splice variants in younger and older men.
Ahtiainen JP, Hulmi JJ, Lehti M, Kraemer WJ, Nyman K, Selänne H, Alen M, Komulainen J, Kovanen V, Mero AA, Philippou A, Laakkonen EK, Häkkinen K.

https://www.ncbi.nlm.nih.gov/pubmed/27231807

Unless you are a physiology geek, you may not understand exactly what the name of the study means. However the following study, published in 2007, looked at a total of 596 genes. Approximately, half of those genes decrease their expression with the aging process and half increase their protein expression with the aging process. When they put the older subjects on a resistance training program, everything reversed. The genes that increased their expression with the aging process decreased and the genes that decreased their protein expression with the aging process increased.

The name of this study is simply the strongest recommendation for participating in a strength training program that I have ever seen. Strength training is the closest thing we have to the fountain of youth!

Resistance Exercise Reverses Aging in Human Skeletal Muscle
Simon Melov , Mark A. Tarnopolsky , Kenneth Beckman, Krysta Felkey, Alan Hubbard
Published: May 23, 2007 http://dx.doi.org/10.1371/journal.pone.0000465

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0000465

Ryan A. Hall



journal.pone.0000465.g001


Figure 1. Differential Gene expression in physiologically normal individuals with age.



journal.pone.0000465.g003


Figure 3. Gene expression changes associated with aging are reversed to youthful levels after 6 months of exercise training.



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